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SUMMARY:BSU Seminar: “Sample size considerations for the design clinical
  trials – quantifying the target difference and the target no-difference
 ” - Prof Steven Julious\, University of Sheffield
DTSTART:20190221T140000Z
DTEND:20190221T150000Z
UID:TALK115996@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:One of the most of the important steps in any clinical trial d
 esign is the calculation of the sample size calculation.  From this the st
 udy timelines and financial budgets are calculated.  A major driver in the
  sample size calculation size calculation is the target difference (for a 
 superiority trial) or the target no-difference (for a non-inferiority tria
 l).\n\nHow these are quantified will impact on their estimation.  The most
  common approach is to review the treatment effects that have been observe
 d previously.  The can be issues with this approach as what has been seen 
 in the past does not carry forward to future trials.\n  \nFor a superiorit
 y trial an inaccurately quantified target difference could mean the study 
 does not have sufficient sample size and so inadequate power to show an ef
 fect.  For a non-inferiority trial the effect of an inaccurately quantifie
 d non-inferiority limit could be consider more of an issue as it could mea
 n false conclusions of no effect are made. \n\nIn this talk will highlight
  the issues with quantifying target differences or non-inferiority limits 
 and will make practical recommendations.\n
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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