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SUMMARY:Temporal Scaling of C. elegans Ageing - Dr Nicholas Stroustrup
DTSTART:20190205T130000Z
DTEND:20190205T140000Z
UID:TALK116413@talks.cam.ac.uk
CONTACT:Minna Taipale
DESCRIPTION:Ageing produces a wide distribution of lifespan even among iso
 genic individuals housed in controlled environments. Using our automated i
 maging platform\, we found that many lifespan-extending interventions prod
 uce a similar effect on the C. elegans lifespan distribution--a temporal s
 caling. Interventions that produce this apparent stretching in respect to 
 time include changes in diet and temperature\, exposure to oxidative stres
 s\, and the disruption of genes including the insulin/IGF receptor\, HSF-1
 \, and DAF-16/FOXO. These interventions all produce distinct molecular-lev
 el changes\, yet ultimately yield a similar scaling of the aging dynamics.
   To understand this phenomenon\, we ran a series of simulations in which 
 we found that temporal scaling can arise as a general response of highly-i
 nterconnected complex networks.  When components (e.g molecular mechanisms
 ) are embedded in highly-interconnected networks\, declines in the functio
 n of small sub-networks can propagate to yield a homogeneous effect on the
  dynamics of the system as a whole.  These results a provide a new\, empir
 ically-grounded framework for linking molecular interventions to their sys
 temic effects in ageing.
LOCATION:Department of Biochemistry\, Sanger Building Jean Thomas Lecture 
 Theatre
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