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SUMMARY:THIS SEMIAR IS NOW CANCELLED  -                                   
                          'Cell Plasticity in Colon Carcinogenesis' - Profe
 ssor Florian Greten\, Institute for Tumor Biology and Experimental Therapy
 \, Frankfurt
DTSTART:20190115T113000Z
DTEND:20190115T123000Z
UID:TALK116614@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:*Abstract*\n\nThe tumor microenvironment is composed of differ
 ent cells that can be grouped into three classes: cancer-associated fibrob
 lasts\, vascular cells and infiltrating immune cells. The relative abundan
 ce of these respective cell types as well as their polarization profile ca
 n greatly vary and often predicts prognosis and response to therapy. Cells
  of all three groups can control tumor cell proliferation\, cell death\, g
 rowth suppressor evasion\, energy metabolism\, angiogenesis\, immune evasi
 on as well as invasion in a non-autonomous manner. Thus\, it has become un
 equivocally evident that tumor development depends on the intricate recipr
 ocal interplay of mutagenized tumor cells with their local and distant mic
 roenvironment. Cytokines and other signal proteins control the plasticity 
 of stromal\, tumor and cancer stem like cells in an autocrine and paracrin
 e manner thereby shaping the complex cellular contexture\, which ultimatel
 y forms a pro- or anti-tumorigenic milieu. A detailed understanding of the
  cellular and molecular mechanisms underlying these complex interactions o
 f tumor\, stroma and immune cells may help to identify novel therapeutic t
 argets. We recently identified signaling pathways during early and late tu
 morigenesis that highlight the importance of tumor cells for T cell polari
 zation and suppression of adaptive immunity and that help to understand wh
 y stroma-rich colon tumors may be associated with a worse prognosis. 
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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