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SUMMARY:LMB Seminar Series-Epigenetic inheritance in mammals - Anne Fergus
 on Smith\, Department of Genetics\, Wellcome Trust Senior Investigator
DTSTART:20190130T110000Z
DTEND:20190130T120000Z
UID:TALK116623@talks.cam.ac.uk
CONTACT:72112
DESCRIPTION:Epigenetic modifications\, such as DNA methylation\, contribut
 e to the regulation of genome function. Such modifications can be heritabl
 y maintained in somatic lineages\, however\, between generations epigeneti
 c modification are erased and re-established twice ensuring that most epig
 enetic states are not perpetuated across generations. Nonetheless\, epigen
 etic inheritance is evident at genomic imprints – regions of the genome 
 that regulate the parental origin-specific gene expression that is importa
 nt for pre and postnatal development\, neurological processes and the cont
 rol of metabolic resources. Mechanisms regulating epigenetic inheritance a
 t imprints will be discussed. \nWe have considered whether epigenetic inhe
 ritance occurs in a wider context. Inspired by a classic mouse model cause
 d by the insertion of a retrotransposon upstream of the agouti coat colour
  locus (Avy) exhibiting non-genetic transmission of coat colour across gen
 erations\, we have conducted a screen for retrotransposons exhibiting prop
 erties of Avy. Our studies have provided novel insights into the epigeneti
 c control of the repeat genome\, the contribution of epigenetically modula
 ted repeats to genome function\, and the mechanisms of non-genetic inherit
 ance of phenotypes across generations. \nKazachenka\, Bertozzi et al.\, Ce
 ll\, 175(6):1717 (2018)\nTakahashi\, Coluccio et al.\, Genes & Development
 \, 33(1-2):49-54 (2019)\n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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