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SUMMARY:LMB Seminar Series - Synthesis and hydrolysis of the gram-positive
  cell wall: revisiting old models with new data - David Rudner\, Dept. of 
 Microbiology and Immunobiology\, Harvard Medical School
DTSTART:20190503T100000Z
DTEND:20190503T110000Z
UID:TALK116647@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Expansion of the bacterial cell wall is essential for growth b
 ut the mechanisms underlying the synthesis and hydrolysis of this three-di
 mensional meshwork remain poorly understood. A deeper understanding of the
 se processes have the potential to define new vulnerabilities for therapeu
 tic interventation. In my seminar\, I will describe our discovery of a new
  and broadly conserved family of cell wall polymerases and our studies of 
 two key cell wall hydrolases. With this information in hand\, I will revis
 it and attempt to refine models championed by Koch and Doyle in the 1980s 
 for how gram-positive bacteria remodel their cell wall during growth. Alon
 g the way\, I will describe a novel signaling pathway that functions to ma
 intain cell wall hydrolysis activity during growth..
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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