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SUMMARY:Forces controlling protein interactions: theory and experiment - A
 lbert Bartok-Partay
DTSTART:20080502T150000Z
DTEND:20080502T153000Z
UID:TALK11676@talks.cam.ac.uk
CONTACT:James Kermode
DESCRIPTION:D. Leckband and S. Sivasankar\, Forces controlling protein int
 eractions: theory and experiment\, "Colloids and Surfaces B: Biointerfaces
 \, 14\, 83 (1999)":http://dx.doi.org/10.1016/S0927-7765(99)00027-2\n\nThis
  work reviews both the theory and experimental measurements of the fundame
 ntal forces that control protein solution behavior. In addition to the Der
 jaguin–Landau–Verwey–Overbeek (DLVO) forces\, we also discuss the re
 lative importance of hydrodynamic\, solvation\, and lock-and-key interacti
 ons in controlling protein solution behavior. The more common computationa
 l methods used to calculate both electrostatic and van der Waals potential
 s are described. Particular attention is given to the differences between 
 proteins and ideal colloidal particles\, and the computational methods use
 d to address those differences. In addition to theoretical investigations 
 of protein interactions\, the results of recent direct measurements of the
  forces governing protein interactions are reviewed. These experimental re
 sults provide not only measurements against which the theories can be test
 ed\, but also demonstrate directly the relative importance of both DLVO an
 d non-classical DLVO forces in the control of protein behavior.
LOCATION:TCM Seminar Room\, Cavendish Laboratory
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