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SUMMARY:Phenotyping iPS-CM's with light - Matthew Daniels\, Oxford
DTSTART:20190221T130000Z
DTEND:20190221T140000Z
UID:TALK117358@talks.cam.ac.uk
CONTACT:47770
DESCRIPTION:We lack the ability to study cardiomyocyte form (sarcomere spa
 cing\, orientation\, density) and function (calcium\, voltage\, force) in 
 living cells. This is especially true of the amorphous IPS derivative at s
 ingle cell scale. I will show how\, and explain why existing dye based app
 roaches cannot be considered suitable partners in studies of contractility
 . Instead\, we make proteins to reveal IPS-CM form and function in real-ti
 me\, in the absence of contractile impairment\, and in combination with qu
 antitative force measurement\, even when buried in the myofilament itself.
LOCATION:School of Clinical Medicine\, Lecture Theatre Two
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