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SUMMARY:Transcriptional dependencies in cancer - Christopher Vakoc\, Cold 
 Spring Harbor Laboratory
DTSTART:20191011T120000Z
DTEND:20191011T130000Z
UID:TALK117466@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:A reprogrammed transcriptional state is required for malignant
  transformation\, a process that can render cancer cells addicted to speci
 fic transcriptional regulators. Our research focuses on identifying transc
 riptional addictions in cancer using genetic screens\, followed by a deep 
 investigation of underlying mechanisms. Over several years\, our studies h
 ave reinforced the role of sequence-specific DNA binding transcription fac
 tors as the premier transcriptional addictions deserving of therapeutic in
 tervention\, such as MYB in acute myeloid leukemia and POU2F3 in small cel
 l lung cancer. However\, such targets are among the most challenging to ta
 rget directly with small-molecules\, which has motivated our efforts to st
 udy how TF oncoproteins interact with their cofactors\, such BRD4\, p300\,
  TFIID\, and Mediator. My presentation will discuss two of our recently id
 entified transcriptional addictions in cancer identified via genetic scree
 ns and our efforts aimed at revealing properties that distinguish effectiv
 e from ineffective transcriptional therapies.
LOCATION:CRUK CI Lecture Theatre
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