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SUMMARY:Microbial evolution in the human gut - Pauline Scanlan (University
  College Cork)
DTSTART:20190312T130000Z
DTEND:20190312T140000Z
UID:TALK117535@talks.cam.ac.uk
CONTACT:77602
DESCRIPTION:Antagonistic coevolution (AC) is defined as the reciprocal sel
 ection for host resistance and parasite infectivity. Bacteria and their ly
 tic viral parasites\, bacteriophages or phages\, are ubiquitous and highly
  abundant components of the biosphere and AC between bacteria and phages i
 s now recognised to play a key role in driving and maintaining microbial d
 iversity. Consequently\, AC is predicted to affect all levels of biologica
 l organisation\, from the individual to ecosystem scales. Nonetheless\, we
  know very little about bacteria–phage AC in perhaps the most important 
 and clinically relevant microbial ecosystem known to mankind – the human
  gut microbiome. In this seminar I will present data emerging from the tem
 poral analysis of populations of bacteria and phages isolated from the hum
 an gut as well as results from a complementary in vitro study that was dev
 eloped to study AC dynamics between populations of gut bacteria and associ
 ated phages. Finally\, I will discuss these data in the context of AC and 
 its potential role in driving observed patterns of intra- and interindivid
 ual variation in the gut microbiome together with detailing the functional
  consequences of such AC-driven microbial variation for human health and d
 isease.
LOCATION:Part II Lecture Theatre\, Department of Zoology \, Downing Street
 \, CB2 3EJ
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