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SUMMARY:Upside-Down and Inside-Out: The Biomechanics of Cell Sheet Folding
  - Prof Ray Goldstein ( DAMTP\, University of Cambridge)
DTSTART:20190118T130000Z
DTEND:20190118T140000Z
UID:TALK117652@talks.cam.ac.uk
CONTACT:Joseph Ibrahim
DESCRIPTION:Deformations of cell sheets are ubiquitous in early animal dev
 elopment\, often arising from a complex and poorly understood interplay of
  cell shape changes\, division\, and migration. I will describe our work o
 n perhaps the simplest example of cell sheet folding: the “inversion” 
 process of the algal genus Volvox\, during which spherical embryos turn th
 emselves inside out through a process hypothesized to arise from cell shap
 e changes alone. We have used light sheet microscopy to obtain the first t
 hree-dimensional visualizations of inversion in vivo\, and developed the f
 irst theory of this process\, in which cell shape changes appear as local 
 variations of intrinsic curvature\, contraction and stretching of an elast
 ic shell. Our results support a scenario in which these active processes f
 unction in a defined spatiotemporal manner to enable inversion.
LOCATION:JDB Seminar Room\, CUED
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