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SUMMARY:How We Make a Billion Antibodies: Genetics and Epigenetics - Dr An
 ne Corcoran
DTSTART:20190305T180000Z
DTEND:20190305T200000Z
UID:TALK117721@talks.cam.ac.uk
CONTACT:Maya Ben Yami
DESCRIPTION:Our B lymphocytes (white blood cells) make millions of differe
 nt antibodies every day to be ready to fight the billions of infections we
  may encounter. We only have 200 antibody-encoding genes in our genome –
  so how do we do this? The answer is a multi-layered story of ingenious sh
 aring of resources in the world of the nucleus\, of enormous pieces of DNA
  looping in 3D space to bring genes together\, using global epigenetic pro
 cesses including non-coding RNA transcription\, while each gene’s local 
 chromatin neighbourhood also plays a vital role in cutting and pasting gen
 e segments together to maximise our defences.  \n\nFollowing a postdoc at 
 the LMB\, Dr Corcoran established her group at the Babraham Institute\, Ca
 mbridge in 2000 to identify and study these recombination mechanisms and t
 heir dysregulation in leukaemia\, immunodeficiency and ageing.
LOCATION:Pfizer Lecture Theatre\, Department of Chemistry\, Lensfield Road
 \, Cambridge
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