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SUMMARY:Mitochondrial biogenesis: dynamic complexes for a dynamic organell
 e - Professor Mike Ryan | Monash Biomedicine Discovery Institute 
DTSTART:20190131T150000Z
DTEND:20190131T160000Z
UID:TALK118081@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Defects in OXPHOS is a major cause of mitochondrial disease wi
 th defects in the first enzyme\, complex I\, being a major contributor to 
 disease. Complex I is composed of 45 subunits in humans\, making it one of
  the largest known multi-subunit membrane protein complexes. The enzyme is
  assembled via a series of intermediate modules involving the dynamic inte
 rplay between a suite of assembly factors. The dynamic nature of mitochond
 ria is also linked to metabolic and disease states\, stress and quality co
 ntrol. Fission and fusion is co-ordinated by a group of dynamin family GTP
 ases. Mitochondrial fission is executed by dynamin related protein 1 (Drp1
 ) which is recruited to the outer membrane by adaptor proteins Mff and MiD
 49/51. Other players involved in fission include mitochondrial constrictio
 n machineries involving the ER\, actin and other dynamins. The machineries
  involved in complex I assembly and mitochondrial fission will be outlined
 .
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, C
 ambridge Biomedical Campus
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