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SUMMARY: Evolution of protein complexes and protein interaction networks -
  Sarah Teichmann (MRC Laboratory of Molecular Biology)
DTSTART:20080521T125000Z
DTEND:20080521T133500Z
UID:TALK11841@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:   There is an abundance of data on protein interactions and p
 rotein complexes\, both from conventional small-scale experiments collecte
 d over the decades\, including three-dimensional structures\, and more rec
 ently by large-scale functional genomics experiments. We can now draw on t
 he information available about protein interactions in order to study the 
 evolution of interactions. We have shown that interactions\, just like ind
 ividual proteins\, frequently emerge by duplication and divergence. The du
 plication of a protein that engages in protein-protein interactions raises
  issues about the stoichiometry and equilibrium of protein complexes when 
 the quantity of one component increases. Nevertheless\, our results indica
 te that most iteractions and complexes have evolved by step-wise duplicati
 ons of individual proteins engaged in interactions. We show that duplicate
 d complexes retain the same overall function\, but have different binding 
 specificities and regulation\, revealing that duplication is associated wi
 th functional specialization[1\,2].\n       From analysis of crystal struc
 tures of proteins as well as the domain architectures of multi-domain prot
 eins\, it is clear that physical interactions between identical or homolog
 ous domains and protein chains are extremely common [3\,4]. How have this 
 particular class of interactions evolved\, and how do they fold and assemb
 le [5]? These questions will be addressed during the talk.\n\nReferences\n
 \n[1] Pereira-Leal JB\, Teichmann SA.(2005) Novel specificities emerge by 
 stepwise duplication of functional modules. Genome Res. 15\,552-9.\n\n[2] 
 Pereira-Leal\, J.\, Levy\, E.D.\, Kamp\, C. & Teichmann\, S.A. (2007) Evol
 ution of protein complexes by duplication of homomeric interactions. Genom
 e Biol\, 8\, R51.\n\n[3] Levy\, E.D.\, Pereira-Leal\, J.\, Chothia\, C. & 
 Teichmann\, S.A. 3DComplex: a hierarchical classification of protein quate
 rnary structure. PLoS Comp. Biol.\, 2:e155.\n\n[4] Wright CF\, Teichmann S
 A\, Clarke J\, Dobson CM. (2005) The importance of sequence diversity in t
 he aggregation and evolution of pr oteins. Nature\, 438\, 878-81.\n\n[5] L
 evy\, E.D. Boeri-Erba\, E.\, Robinson\, C.V.\, Teichmann\, S.A. (2008) Ass
 embly reflects evolution of protein complexes. Nature\, in press.\n\n
LOCATION:MR2\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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