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SUMMARY:From dyfunction of the PINK1/Parkin pathway to Parkinson’s disea
 se - Dr Olga Corti | ICM\, Paris 
DTSTART:20190206T150000Z
DTEND:20190206T160000Z
UID:TALK118609@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Mitochondrial dysfunction has long been suspected to play a ro
 le in the pathogenesis of Parkinson’s disease. This hypothesis has recei
 ved strong support in recent years\, with the discovery of gene responsibl
 e for familial Parkinson’s disease playing roles in mitochondrial mainte
 nance. The products of the PINK1 and PARK2 (Parkin) genes cooperate in sen
 sing mitochondrial dysfunction and linking it to the activation of protect
 ive mitochondrial quality control programs\, including mitophagy. Despite 
 the remarkable advances in our understanding of the molecular mechanisms b
 y which PINK1 and Parkin promote mitophagy\, little is known about how the
 ir dysfunction leads to neuronal degeneration. I will present recent effor
 ts from our laboratory to characterize mechanisms by which PINK1 and Parki
 n preserve the quality of mitochondria and understand how dysfunction of t
 his multifunctional pathway leads to neuronal degeneration in Parkinson’
 s disease.
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, C
 ambridge Biomedical Campus
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