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SUMMARY:Molecular basis of mitochondrial DNA replication in mammalian cell
 s - Prof Maria Falkenberg | University of Gothenburg 
DTSTART:20191112T160000Z
DTEND:20191112T170000Z
UID:TALK118636@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Human mitochondria contain a small double-stranded DNA genome 
 (mtDNA). The genome is dense in information and contains genes for 2 rRNAs
 \, 22 tRNAs\, and 13 mRNAs that code for components of the respiratory cha
 in. Loss of mtDNA or mutations can cause a number of different mitochondri
 al diseases. The mitochondrial replisome contains four essential factors: 
 DNA polymerase γ\, the DNA helicase TWINKLE\, the mitochondrial single st
 randed DNA binding protein\, mtSSB\, and the mitochondrial RNA polymerase\
 , POLRMT\, which synthesizes primers required for initiation of mtDNA synt
 hesis. Recently\, two additional proteins\, MGME1 and RNase H1 were also s
 hown to be involved in mtDNA replication.  I will discuss how these factor
 s cooperate to replicate the mitochondrial genome. I will also discuss how
  disease-causing mutations in the different proteins can affect the functi
 on of this molecular machinery. 
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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