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SUMMARY:Recent progress in electron cryomicroscopy - Richard Henderson\, M
 RC Laboratory of Molecular Biology
DTSTART:20190403T093000Z
DTEND:20190403T103000Z
UID:TALK118981@talks.cam.ac.uk
CONTACT:Gabriella Heller
DESCRIPTION:In the last few years\, single particle electron cryomicroscop
 y (cryoEM) \nhas experienced a quantum leap in its capability\, due to imp
 roved \nelectron microscopes\, better detectors and better software\, and 
 this is \nrevolutionising structural biology. Using the technique invented
  by \nJacques Dubochet and his colleagues\, a thin film containing a suspe
 nsion of the macromolecules of interest is plunge-frozen into liquid ethan
 e at liquid nitrogen temperature\, creating a frozen sample in which \nind
 ividual images of the structures can be seen in many different \norientati
 ons. Subsequent computer-based image analysis is then used to \ndetermine 
 the three-dimensional structure\, frequently at near-atomic \nresolution. 
 I will describe some recent results and discuss remaining \nbarriers to pr
 ogress. CryoEM is already a very powerful method\, but \nthere are still m
 any improvements that can be made before the approach \nreaches its theore
 tical limits.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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