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SUMMARY:A super-resolved look at synthetic nanomaterials - Lorenzo Alberta
 zzi\, Institute for Bioengineering of Catalonia (IBEC)
DTSTART:20190220T103000Z
DTEND:20190220T113000Z
UID:TALK118984@talks.cam.ac.uk
CONTACT:Will Arter
DESCRIPTION:Nanomaterials revolutionized the field of biomedicine introduc
 ing innovative approaches towards drug delivery\, molecular imaging\, rege
 nerative medicine and biosensing. However\, despite the large investments 
 in nanotechnology the translation into clinical applications is still unsa
 tisfactory. One of the main reasons is the lack of knowledge about the beh
 avior of nanostructures in the biological environment that makes the ratio
 nal design of effective materials extremely challenging. \nThe main aim of
  our group is to use advanced microscopy techniques to understand nanomate
 rials structure and their interactions of with living matter and to exploi
 t this information to design novel devices for biomedical applications wit
 h a particular focus on drug delivery. To this goal we employ advanced opt
 ical imaging techniques such as super resolution microscopy to visualize a
 nd understand the molecular interactions of nanomaterials with their cellu
 lar targets in unprecedented detail. Super resolution microscopy technique
 s such as stochastic optical reconstruction microscopy (STORM) and point a
 ccumulation for imaging in nanoscale topography (PAINT) offer nanometric r
 esolution and multicolor ability\, therefore they are ideal tools to study
  nano-sized multicomponent functional objects in vitro and in cells. This 
 allows to get a closer “look” at the mechanisms of the key phenomena r
 esponsible for device performances such as particle stability\, protein co
 rona and targeting. The fundamental knowledge acquired will pave the way t
 owards the “microscopy-guided” design of novel nanomaterials for drug 
 and gene delivery.\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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