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SUMMARY:Seminar – Longitudinal growth modeling: a tool for genetic disco
 very - Dr Diana Cousminer\, Children’s Hospital of Philadelphia\, Univer
 sity of Philadelphia
DTSTART:20190215T133000Z
DTEND:20190215T143000Z
UID:TALK119095@talks.cam.ac.uk
CONTACT:Paul Browne
DESCRIPTION:Distinct growth patterns during adolescence correlate with adv
 erse health outcomes such as poor cardiometabolic health and risk for oste
 oporosis\, but the genetic mechanisms mediating differences in growth traj
 ectories remain largely unknown. Longitudinal modeling using SuperImpositi
 on by Translation and Rotation (SITAR) breaks down complex growth trajecto
 ries into three components\, “size”\, “timing”\, and “velocity.
 ” We utilize these parameters as phenotypes for input into genome-wide a
 ssociation studies (GWAS)\, to better understand the genetic determinants 
 of increase in bone mineral density at distinct skeletal sites and height 
 growth.
LOCATION:Seminar room 2\, University of Cambridge School of Clinical Medic
 ine\, CB2 0SP
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