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SUMMARY:Melville Lectures &quot\;Breakable and self-assembled materials: S
 ynthesis and applications&quot\; - Professor Luisa de Cola\, Institut de S
 cience et d'Ingénierie\, Supramoléculaires\, Université de Strasbourg
DTSTART:20190211T143000Z
DTEND:20190211T153000Z
UID:TALK120103@talks.cam.ac.uk
CONTACT:79612
DESCRIPTION:Despite the substantial progress that has been made in biomate
 rials synthesis and functionalization\, the challenge of delivery in vivo 
 in desired organs biomolecules or drugs and to mimic the ECM with implants
  that are able to reduce immunoresponse is still unmet. \nTowards this aim
 \, we reported a novel biocompatible hydrogel with the ability to release 
 a migration-inducing factor\, for the recruitment of stem cells. The hydro
 gel is a composite made of breakable container –type materials able to r
 espond to an external stimulus [1]. In particular we devoted much effort i
 n the creation of “containers’ able to break in small fragments (<5 nm
 ) by a redox reactions\,[2] enzymatic degradation\,[3] and pH [4] . They c
 an also be capsules in which large biomolecules such as enzymes and protei
 ns can be entrapped and release on demand [5]. The hydrogels that contain 
 such nanoparticles are formed in physiological conditions\, without any ca
 talyst and at room or at body temperature. They are perfectly biocompatibl
 e and can be made degradable. Cells are able to populate and proliferate i
 n the matrices and even stem cells are able to grow and differentiate. Int
 erestingly these soft materials can be injected as liquid and are able to 
 solidify in few seconds or even in milliseconds in different tissues and o
 rgans. We have demonstrated that indeed the biocompatibility of the system
 s is very high and we have started to use them in different applications s
 uch as wound repair and support for tumor resection [6]. Indeed at the end
  of my talk I wish to show some of these applications in vivo and to give 
 some perspectives.\n\n[1] F. Fiorini\, et al. Small\, 2016\, 12\, 4881\n[2
 ] L. Maggini\,  et al. Nanoscale\, 2016\, 8\, 7240\n[3] L. Maggini\, et al
 . Chem. Eu. J.\, 2016\, 22\, 3697\n[4] L. Travaglini\, et al. Mater. Chem.
  Front.\, 2019\, 3\, 111\n[5] E.A. Prasetyanto\, et al. Angew. Chem. Int. 
 Ed. 2016\, 55\, 3323.\n[6] G. Alonci et al. ACS Appl. Bio Mater.\, 2018\, 
 1\, 1301.\n
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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