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SUMMARY:Genomic Regulatory Network Models for Developing Blood Stem Cells 
 - Dr. Bertie Gottgens (Haematology)
DTSTART:20080521T152500Z
DTEND:20080521T161000Z
UID:TALK12024@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:Characterisation of the regulatory networks regulating stem ce
 lls will be \nvital to harness their full potential for both therapeutic a
 nd drug \ndiscovery applications.  Our group has a long track record of st
 udying \ntranscriptional regulatory elements active in blood stem cells an
 d provided \nthe first molecular characterisation of any element active in
  adult stem \ncells.  The group has also developed bioinformatic tools to 
 identify \nfunctionally related regulatory elements and is thus defining k
 ey \ncomponents of an emerging blood stem cell network currently composed 
 of 15 \ntranscription factors with over 40 experimentally verified connect
 ions. \nWithin this network\, we have identified a regulatory circuit made
  up of \nGata2\, Fli1 and Scl/Tal1 and their enhancers\, Gata2-3\, Fli1+12
 \, and Scl+19. \nThe three blood stem cell enhancers are bound by each of 
 these \ntranscription factors and thus form a fully connected triad.  By p
 erforming \nquantitative measurements of the regulatory interactions withi
 n this \nnetwork motif\, we have been able to build a mathematical model d
 escribing \nthe function of this regulatory circuit in blood stem cells.  
 The \nGata2/Fli1/Scl network subcircuit constitutes the first example of a
 ny \nnetwork motif operating during the specification of mammalian stem ce
 lls \nwhere all the individual components have been identified and is alre
 ady \nallowing us to develop novel hypotheses for experimental validation.
 \n\n
LOCATION:MR2\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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