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SUMMARY:Mitochondrial dynamics in muscle physiopathology - Professor Marco
  Sandri | University of Padova\, Italy 
DTSTART:20190703T140000Z
DTEND:20190703T150000Z
UID:TALK120403@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Mitochondrial quality control is essential in highly structure
 d cells such as neurons and muscles. In skeletal muscle the mitochondrial 
 shaping machinery and mitophagy are altered in different physiopathologica
 l conditions that are characterized by muscle loss and weakness. The abnor
 mal mitochondria signal to the nucleus to induce several signaling pathway
 s that control proteostasis\, inflammatory response and senescence. Import
 antly\, the shape of the mitochondrial network more than mitochondrial fun
 ction is an important factor for the activation of specific pathways that 
 control peculiar phenotypes. Fusion defect triggers sarcopenia and systemi
 c ageing while fission impairment causes myopathy. Here\, I will present t
 he latest data that connect mitochondrial network to signaling pathways th
 at controls muscle mass.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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