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SUMMARY:Mitochondrial DNA maintenance in non-standard model systems - Prof
 essor Torsten Ochsenreiter | University of Bern 
DTSTART:20191016T140000Z
DTEND:20191016T150000Z
UID:TALK120406@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Trypanosomes are single celled eukaryotes that are only distan
 tly related to the major model systems for mitochondrial biology\, like ye
 ast\, mouse or human. Different from these model systems trypanosome cells
  contain only one mitochondrial organelle with a singular genome (mt-genom
 e). Replication and segregation of the mt-genome is tightly integrated int
 o the cell cycle and a large number of proteins are involved in these two 
 processes. In recent years we and others used a combination of biochemical
  and super resolution microscopy approaches to characterized the molecular
  components involved in proper segregation. We have now a model that descr
 ibes the assembly of the segregation machinery that spans the cytoplasm\, 
 the two mitochondrial membranes as well as the mitochondrial matrix. The p
 resentation will also aim to compare the current status in trypanosomes to
  the other major model systems.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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