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SUMMARY:Male germline epigenetic priming for future development - Dr Shini
 chi Tomizawa\; Department of Histology and Cell Biology\, Yokohama City Un
 iversity
DTSTART:20190307T130000Z
DTEND:20190307T140000Z
UID:TALK120883@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Evidence suggests that mammalian male germ cells carry the epi
 genome primed for embryonic development. However\, the mechanisms underlyi
 ng establishment and transmission of germline epigenetic information remai
 n unclear. Recently\, we found that the histone methyltransferase Kmt2b co
 nveys H3K4me3 to prime the spermatogonial stem cell epigenome for spermato
 genesis and embryonic development in two distinguishable ways. Because Kmt
 2b also primes the ES cell chromatin\, we propose that Kmt2b has the capac
 ity to prime stem cells epigenetically.
LOCATION:Babraham - The Cambridge Building - The Kings Hedges Room
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