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SUMMARY:Rewiring of mTORC1-autophagy pathways in senescence and melanoma -
  Dr Berni Carroll\; University of Bristol 
DTSTART:20190308T130000Z
DTEND:20190308T140000Z
UID:TALK120886@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Ageing and age-related diseases such as cancer are characteris
 ed by the dysregulation of cell growth pathways. In healthy cells\, growth
  is controlled by the dynamic balance between biosynthesis\, degradation a
 nd recycling mediated\, in part by the mTORC1-autophagy pathway. Cellular 
 stress such as oncogene activation and DNA damage can cause senescence or 
 transformation which are associated with a comprehensive rewiring and re-e
 quilibrium between these processes. I will be presenting data detailing ho
 w mTORC1 activity becomes insensitive to nutrient withdrawal in senescent 
 and melanoma cells which is mediated by gross changes in the autophagy-lys
 osome pathway. Ultimately\, I am interested in understanding the mechanism
 s that enable cells to adapt and harness catabolic processes to support gr
 owth and survival. 
LOCATION:Babraham - The Cambridge Building - The Kings Hedges Room
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