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SUMMARY:Paracoccus denitrificans oxidative phosphorylation\, retentions\, 
 gains\, losses\, and lessons en route to mitochondria - Professor Stuart F
 erguson | University of Oxford 
DTSTART:20190925T140000Z
DTEND:20190925T150000Z
UID:TALK121192@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:There are many similarities between the oxidative phosphorylat
 ion apparatus\nof mitochondria and those found in the cytoplasmic membrane
 s of\nalpha-proteobacteria\, exemplified by Paracoccus denitrificans\, the
  choice of which will be explained.\nThese similarities will be reviewed a
 longside consideration of the differences\nbetween mitochondrial and bacte
 rial counterparts\, as well as the loss from\nthe modern mitochondria of m
 any of the bacterial respiratory proteins.\nThe assembly of c-type cytochr
 omes is of particular evolutionary interest\nas the post-translational app
 aratus used in the alpha-proteobacteria is\nfound in plants\, and for exam
 ple in other eukyarotic species\, including algae of\nvarious kinds and ja
 kobids\, but has been superseded by\ndifferent systems in mitochondria of 
 metazoans and trypanosomatids. All\nmitochondrial cytochromes c have the N
 -terminal sequence feature that is\nrecognised by the metazoan apparatue w
 hereas the bacterial counterparts\ndo not\, suggesting that the loss of th
 e bacterial system from eukaryotes\noccurred in the context of an already 
 present recognition sequence in the\neukaryotic cytochromes. Interestingly
 \, in the case of cytochromes c1 the\nputative recognition features for th
 e metazoans appear to be substantially\nalready present in the bacterial p
 roteins. The ability to prepare from P. denitrificans\ninverted membrane v
 esicles with classic respiratory control presents\na valuable system from 
 which to draw lessons concerning the long\ndebated topic of what controls 
 the rates of respiration and ATP synthesis\nin mitochondria. If time allow
 s\, the recent discovery in two other labs of bacterial extracellular wire
 s composed solely of mutimers of a hexheme c-type cytochrome will be illus
 trated.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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