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SUMMARY:The parallelism of evolution of multi-drug resistant clones - Prof
 essor Alan McNally\, Institute of Microbiology and Infection\, College of 
 Medical and Dental Sciences\, University of Birmingham
DTSTART:20190612T150000Z
DTEND:20190612T160000Z
UID:TALK121354@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Escherichia coli is an extremely diverse bacterial species com
 posed of thousands of distinct lineages. Despite many of these lineages (p
 resumably) inhabiting identical niches\, and therefore undergoing identica
 l selection pressures\, only a handful of lineages have emerged as dominan
 t\, globally disseminated MDR clones. Large scale genomic analysis of thes
 e MDR clones\, and contextual comparison against the background population
  from which they emerge\, has allowed us to identify a number of key evolu
 tionary steps in the emergence of these MDR clones\, and their parallelism
  across a number of the most globally dominant MDR clones. Combining genom
 ics with experimental evolution and classical molecular microbiology is al
 lowing us to confirm these key mechanisms that underpin the evolution of s
 uccessful MDR clones of E. coli
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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