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SUMMARY:Skin pharmacokinetics and anti-parasitic pharmacodynamics: towards
  the design of new treatments for cutaneous leishmaniasis - Dr Katrien Van
  Bocxlaer\, London School of Hygiene &amp\; Tropical Medicine
DTSTART:20190515T150000Z
DTEND:20190515T160000Z
UID:TALK121534@talks.cam.ac.uk
CONTACT:80671
DESCRIPTION:Current therapeutics for the protozoan skin disease cutaneous 
 leishmaniasis (CL) are far from optimal\, as they require invasive drug ad
 ministration\, long treatment courses or safety monitoring. Our work focus
 ses on the discovery and development of better\, more patient-friendly dru
 gs for CL. We here propose a strategy based on the evaluation of skin phar
 macokinetics (PK) and anti-parasitic pharmacodynamics (PD) to advance new 
 CL drug candidates from bench to beside.  \n\nEarly on in the drug discove
 ry pathway\, the activity of experimental compounds is tested against a pa
 nel of Leishmania species and in vitro ADME parameters are determined. Dru
 g candidates with favourable properties are advanced into oral and topical
  dose-response efficacy studies in mouse models of L. major and L. mexican
 a CL. In addition\, we compare pharmacokinetics in infected and uninfected
  skin to understand how the physiopathology of CL could be exploited for t
 argeted drug delivery. Finally\, we combine in vivo skin microdialysis and
  bioluminescent imaging to assess free drug exposure and rate of parasite 
 kill directly at the dermal site of infection. \n\nBy combining such PK an
 d PD approaches\, we aim to contribute to the development of new short-cou
 rse\, safe and effective treatments for CL in the form of an oral and/or t
 opical formulation.
LOCATION:Greaves Room\, Department of Pathology\, Tennis Court Road
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