BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Dynamics of hematopoietic stem and progenitor cell differentiation
  in vivo - Prof. Thomas Höfer\; German Cancer Research Center (Deutsches 
 Krebsforschungszentrum\, DKFZ)\, Heidelberg
DTSTART:20190320T120000Z
DTEND:20190320T130000Z
UID:TALK121879@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Recent advances in the non-invasive genetic labeling and barco
 ding of hematopoietic stem cells (HSCs) now allow tracing their fates unde
 r physiological conditions in vivo. We have shown that time-resolved data 
 obtained by lineage tracing of stem cells contain information on the diffe
 rentiation rates of stem and progenitor cells and provided computational i
 nference tools for these rates. Our data\, and data by others\, show remar
 kably low output of HSCs in unchallenged adult mice while multipotent prog
 enitor cells have both high output and considerable self-renewal in vivo. 
 I will review these findings and show how we have recently used the combin
 ation of lineage tracing and computational rate inference to dissect the r
 esponse of the hematopoietic system to various challenges. In response to 
 strong natural challenges\, such as sepsis\, we uncover transiently increa
 sed progenitor cell output whereas the contribution of HSCs to hematopoiet
 ic cell production remains low throughout. Our findings argue in favor of 
 regulatory feedback acting on progenitor cells and do not support the view
  of quiescent HSCs as a reserve for responding to challenges\; I will prop
 ose an alternative function of tip stem cells in hematopoiesis. By way of 
 an outlook\, I will outline how rate inference is also advancing our under
 standing of molecular regulation of gene expression.
LOCATION:Babraham - The Cambridge Building - The Kings Hedges Room
END:VEVENT
END:VCALENDAR