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SUMMARY:Liver Lipid Metabolism and Healthy Ageing: Themes from the Drug Di
 scovery Frontline - Dr Quin Wills\; Novo Nordisk Research Centre\, Oxford
DTSTART:20190426T110000Z
DTEND:20190426T120000Z
UID:TALK121882@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:One in three of us will die from a cardiometabolic disease\, w
 ith current primary treatments directly targeting liver metabolism to lowe
 r blood lipids and blood glucose. It turns out that high blood glucose (du
 e to insulin resistance and type 2 diabetes) correlates with the quantity 
 and types of lipids stored in the liver\, placing liver lipid metabolism a
 t the centre of human cardiometabolic maladies. Fatty liver affects one in
  four of us\, dramatically increasing in prevalence with age and obesity. 
 In addition to affecting cardiometabolic healthspan\, this excess fat can 
 trigger a metabolic stress response in the liver itself\, resulting in cel
 l damage\, inflammation (called non-alcoholic steatohepatitis: NASH)\, and
  cirrhosis. In Europe\, liver cirrhosis is one of the top ten causes of de
 ath. It is the main indication for liver transplantation\, with NASH now e
 merging as its leading aetiology over alcohol and viral hepatitis. Worryin
 gly\, whilst many patients die waiting for a donor\, even mildly NASH dono
 r livers are discarded because these are particularly sensitive to the hyp
 oxic metabolic stress that occurs with transplantation. With no on-label t
 herapies and an expected market of over US$10 billion within five years\, 
 fatty liver has prompted considerable R&D investment. As Head of the Cellu
 lar and Systems Genomics department for the newly formed Novo Nordisk Rese
 arch Centre Oxford - a hybrid industry-academic research institute - my te
 am and I have used biobanks\, in vitro liver organoids\, and even perfused
  ex vivo whole human livers to identify druggable fatty liver targets. Wit
 h some surprising themes.
LOCATION:Babraham - The Cambridge Building - Queen Edith Room
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