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SUMMARY:The regulation and consequences of immune responses during Salmone
 lla infections - Prof. Adam Cunningham\; Institute of Immunology and Immun
 otherapy\, MRC Centre for Immune Regulation\, University of Birmingham
DTSTART:20190724T110000Z
DTEND:20190724T120000Z
UID:TALK121894@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Infections can have devastating consequences on human health. 
 Salmonella infections provide a model to understand the impact of infectio
 n on host homeostasis and immune function as they can cause a spectrum of 
 disease\, from a self-limiting gastroenteritis to enteric fevers that are 
 often fatal. The key factor that predicts severity is the spread of the pa
 thogen beyond the gut\, which emphasises the importance of the ability to 
 restrict this\, through the generation of granuloma-like inflammatory foci
 . Early control of Salmonella infection is wholly dependent upon the innat
 e system\, but clearance requires efficient Th1 responses. How these combi
 ne to effect immune control is only partially understood\, as is what “s
 uccess” and “failure” look like. In this talk\, I will introduce two
  recent areas of study in the group. The first examines how the inflammato
 ry response to Salmonella has unanticipated consequences\, such as the “
 normal” induction of thrombosis in the vessels of infected organs\, and 
 secondly how immune cells and factors combine to help organise immunity to
  control infection. The key factors that I will discuss are how the timing
  and magnitude of immune molecules (e.g. IFNg) and cells (e.g. monocytic c
 ells and Th1 cells) relate to bacterial localisation and the influence of 
 this on enabling control.
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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