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SUMMARY:Non-contrast Enhanced MRI in Central Nervous System - Professor Me
 iyun Wang
DTSTART:20190322T140000Z
DTEND:20190322T150000Z
UID:TALK121957@talks.cam.ac.uk
CONTACT:J.W.Stevens
DESCRIPTION:In this talk\, the applications of three non-contrast enhanced
  advanced MR techniques\, including Diffusion Kurtosis Imaging (DKI)\, Str
 ategically Acquired Gradient Echo (STAGE) and a Length and Offset Varied S
 aturation (LOVARS) in central nervous system (CNS) will be summarized. \nD
 KI has been used to measure non-Gaussian diffusion\, which has the potenti
 al to characterize both normal and pathologic tissue better than diffusion
 -tensor imaging. Some previous researchers have suggested that DKI might p
 rovide more accurate information about water diffusion. Our study showed t
 hat mean kurtosis values may provide additional information and improve th
 e grading of gliomas compared with conventional diffusion parameters.\nSTA
 GE is an advanced Susceptibility weighted imaging (SWI) which can provide 
 multi-contrast images in one scan\, such as T1W\, PDW\, T1 MAP\, PD MAP\, 
 R2* MAP\, SWI\, and even MRA images in 5 minutes. It’s very helpful in e
 arly detecting and evaluating ischemia\, brain trauma and some other CNS d
 iseases.\nLOVARS is a novel Chemical exchange-dependent saturation transfe
 r (CEST) technique with variable length of saturation for 1 pair of offset
 s\, which can detect endogenous macromolecules (e.g. Tumor associated glyc
 oprotein MUC-1) and metabolites. Some preliminary studies have showed that
  LOVARS is not only helpful in early detection and separation of cerebral 
 ischemia and intracranial hemorrhage\, but also in grading glioma\, evalua
 ting the therapy effect and even differentiating treatment effect from tum
 or reoccurrence. Furthermore\, it can also detect and differentiate cerebr
 al ischemia from intracranial hemorrhage at very early stage. So it may ha
 ve the potential to improve the diagnostic flow for early stroke. But its 
 post-processing is still complicated.\n
LOCATION:MR11\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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