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SUMMARY:Segmentation dynamics and diversity in an arthropod cell-based fie
 ld - Professor Hiroki Oda\, JT Biohistory Research Hall\, Osaka\, Japan
DTSTART:20190410T120000Z
DTEND:20190410T130000Z
UID:TALK122176@talks.cam.ac.uk
CONTACT:Kate Criswell
DESCRIPTION:One of the conserved traits of arthropod embryonic development
  is striped expression of homologs of Drosophila segment polarity genes\, 
 including hedgehog (hh)\, which is the outcome of segmentation. Despite th
 is conservation\, processes leading to the stripes are recognized as diver
 sified among arthropod embryos. However\, such varied stripe-forming proce
 sses have not been well characterized from cellular\, quantitative\, and s
 ystems perspectives. In this talk\, we show that the spider Parasteatoda t
 epidariorum model system offers a cell-based field where the stripe-formin
 g processes exhibit distinct dynamic waves\, oscillatory/non-oscillatory t
 raveling waves and bi-/tri-splitting waves\, among the presumptive head\, 
 thoracic\, and opisthosomal (abdominal) regions of the field undergoing ax
 is formation and growth. We find that formation of a global anterior-poste
 rior polarity in the spider embryo relies on Hh signaling and that this Hh
  signaling controls segmentation dynamics and diversity in the field via a
  specific transcription factor gene. Our findings highlight the major cont
 ribution of a Hh signaling network to segmentation in an arthropod cell-ba
 sed field\, providing an example of an evolvable patterning system that is
  comparable to the vertebrate appendage with repetitive elements relying o
 n Hh signaling.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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