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SUMMARY:Cafe Synthetique: Reprogramming Algal Metabolism - Dr Katrin Geisl
 er\, Aleix Gorchs Rovira (Alison Smith Lab\, Department of Plant Sciences)
DTSTART:20190415T170000Z
DTEND:20190415T190000Z
UID:TALK122419@talks.cam.ac.uk
CONTACT:Alexandra Ting
DESCRIPTION:Café Synthetique is the monthly meetup for the Cambridge synt
 hetic biology community with informal talks\, discussion and pub snacks. I
 t is kindly sponsored by Cambridge Consultants.\n\n----\n\n"Nucleus-chloro
 plast genetic circuits in green algae"\nAleix Gorchs Rovira\, Alison Smith
  Lab\, Dept. of Plant Sciences\n\nAlgae can potentially be a green source 
 of high-value compounds. However\, systems that control tight gene express
 ion are lacking. We developed a platform strain that can tightly regulate 
 gene expression of the photosynthetic apparatus but also foreign metabolic
  genes by using RNA-binding proteins called PPR proteins.\n\n"Using synthe
 tic biology to engineer lipid metabolism in marine algae"\nDr Katrin Geisl
 er\, Alison Smith Lab\, Dept. of Plant Sciences\n\nMarine microalgae\, lik
 e the diatom Phaeodactylum tricornutum\, are exciting biotechnology chassi
 s as they grow on alternative water sources. Their ability to accumulate l
 arge amounts of lipids makes them an interesting platform to produce novel
  fatty acids or valuable oils for food and feed. Over the last years\, we 
 and others have developed a range of established and novel DNA parts for t
 he algae P. tricornutum. Using these parts\, we assembled molecular device
 s to manipulate the lipid metabolism in the algae. We are combining metabo
 lic engineering with microfluidic devices for the encapsulation and growth
  of wildtype and transformed microalgae cells in microdroplets\, allowing 
 the analysis of single cells and the screening of them in a high-throughpu
 t manner.
LOCATION:Panton Arms 43 Panton Street CB2 1HL\, Cambridge
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