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SUMMARY:Type-I interferons and microglia: influencing chronic neuropatholo
 gies - Dr Juliet M. Taylor.  Department of Pharmacology &amp\; Therapeutic
 s\, University of Melbourne\, Australia.
DTSTART:20190401T100000Z
DTEND:20190401T110000Z
UID:TALK122488@talks.cam.ac.uk
CONTACT:Shamith Samarajiwa
DESCRIPTION:Neuroinflammation has been implicated in both neurodegenerativ
 e diseases\, however\, it’s contribution to the disease pathogenesis is 
 not well understood. Dr. Taylor’s current work is focussed on understand
 ing the role of the type-1 interferons in modulating this neuroinflammator
 y response in these diseases and has identified a key role for these cytok
 ines in both AD (APP/PS1)(1) and PD (MPTP)(2) mouse models. Our studies al
 so confirmed that blocking type I IFN signaling with a monoclonal antibody
  reduces neuroinflammation and neuronal cell loss induced by MPTP\, with i
 mprovements in behavioral outcomes(2). In this presentation\, Dr. Taylor w
 ill discuss recent work looking at the type-1 IFNs in cell models and anim
 al models of AD and PD\, demonstrating their important role in mediating t
 he early neuroinflammatory response of microglia and also neuronal cell de
 ath in these neurodegenerative diseases.\n\n1. Minter et al.\, (2016) ACTA
  Neuropathologica Comm.\n\n2. Main et al.\, (2016) Glia
LOCATION:Newman Library\, Postdoctoral Centre (Addenbrookes)\, enter via C
 lifford Allbutt building
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