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SUMMARY:Computational Neuroscience Journal Club - Jake Stroud
DTSTART:20190404T103000Z
DTEND:20190404T113000Z
UID:TALK122500@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:Jake Stroud will be presenting:\n\n• Discrete attractor dyna
 mics underlies persistent activity in the frontal cortex\n\n• Hidehiko K
 . Inagaki\, Lorenzo Fontolan\, Sandro Romani & Karel Svoboda\n\n• Nature
  2019\n\n• https://www.nature.com/articles/s41586-019-0919-7\n\nAbstract
 : Short-term memories link events separated in time\, such as past sensati
 on and future actions. Short-term memories are correlated with slow neural
  dynamics\, including selective persistent activity\, which can be maintai
 ned over seconds. In a delayed response task that requires short-term memo
 ry\, neurons in the mouse anterior lateral motor cortex (ALM) show persist
 ent activity that instructs future actions. To determine the principles th
 at underlie this persistent activity\, here we combined intracellular and 
 extracellular electrophysiology with optogenetic perturbations and network
  modelling. We show that during the delay epoch\, the activity of ALM neur
 ons moved towards discrete end points that correspond to specific movement
  directions. These end points were robust to transient shifts in ALM activ
 ity caused by optogenetic perturbations. Perturbations occasionally switch
 ed the population dynamics to the other end point\, followed by incorrect 
 actions. Our results show that discrete attractor dynamics underlie short-
 term memory related to motor planning.
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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