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SUMMARY:LARMOR LECTURE -  Design of Tissue Engineering Scaffolds - Still L
 earning our ABC? - Professor Serena Best\, Department of Materials Science
  and Metallurgy. 18.00 - 19.00
DTSTART:20191014T170000Z
DTEND:20191014T180000Z
UID:TALK122647@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:For many years\, there has been interest in the use of biomate
 rials to replace human tissues damaged by injury or disease.  Over time\, 
 the materials of choice have gradually changed from those that simply offe
 r mechanical support to those that interact directly with the biological e
 nvironment. Focus is now on the recruitment and delivery of biological cel
 ls to assist in the repair process. With this move from tissue replacement
  to cell-mediated tissue reconstruction and regeneration (or tissue engine
 ering)\, there is increasing need for the design of optimised\, porous bio
 material structures – often referred to as “Scaffolds”. By first und
 erstanding the nature of the tissues that we want to regenerate\, it is po
 ssible to address the requirements for particular clinical applications. \
 n\nThis talk will consider two scaffold materials: collagen\, a highly ver
 satile and bioactive natural macromolecule\; and hydroxyapatite\, a calciu
 m phosphate material similar in composition to bone mineral. To optimise t
 issue repair processes\, it is important to understand the influence on ce
 ll behaviour of the structure of the scaffold\, and the interconnections b
 etween the pores within them. Choice of scaffold surface chemistry also al
 lows us to balance scaffold “activity” and mechanical performance. The
 re is also a need to consider an appropriate testing environment to mimic 
 the cellular interactions which take place within the body. \n\nThis talk 
 will cover the recent work undertaken to study the structure and propertie
 s of scaffolds for a range of clinical applications in soft and hard tissu
 e repair. \n
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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