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SUMMARY:A rule based approach to Development - Kim Sneppen (Niels Bohr Ins
 titute\, University of Copenhagen)
DTSTART:20190424T150000Z
DTEND:20190424T160000Z
UID:TALK122755@talks.cam.ac.uk
CONTACT:Nataliia Kuksa
DESCRIPTION:Development of animals proceeds from bulk\, through simple sph
 erical shapes to folds and tubes. Emerging geometrical shapes are robust f
 or a given species and can be maintained when moved to different parts of 
 the embryo or if the size is varied. Despite conceptually similar processe
 s of progression through development\, the resulting geometrical shapes ca
 n be very different between species. How can we reconcile this robustness 
 with overall variability?\n\nThe progression from bulk\, to tubes and fold
 s coincides with the progressive - first apical basal and then planar - po
 larization of cells. To explore if cellular polarization may enable develo
 pment with the ability to create diversity of robust and stable shapes we 
 developed a tool that allows to simulate thousands of polarized cells in 3
 D. We find that cellular polarity enables stable complex folded shapes. Wh
 en set in the context of pancreatic organoids\, one polarity (Apical basal
 ) coupled with differential growth rates is sufficient to explain emergenc
 e of folded lumens in pancreatic organoids. With two\, apical basal and pl
 anar\, mutually perpendicular polarities\, the model recovers main stages 
 of sea urchin gastrulation.\n
LOCATION:Auditorium of Sainsbury Laboratory Cambridge University (Bateman 
 Street)
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