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SUMMARY:Theoretical tool bridging cell polarities with development of robu
 st morphologies - Silas Boye Nissen (University of Copenhagen)
DTSTART:20190411T120000Z
DTEND:20190411T130000Z
UID:TALK122857@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:Despite continual renewal and damages\, a multicellular organi
 sm is able to maintain its complex morphology. How is this stability compa
 tible with the complexity and diversity of living forms? Looking for answe
 rs at protein level may be limiting as diverging protein sequences can res
 ult in similar morphologies. Inspired by the progressive role of apical-ba
 sal and planar cell polarity in development\, we propose that stability\, 
 complexity\, and diversity are emergent properties in populations of proli
 ferating polarized cells. We support our hypothesis by a theoretical appro
 ach\, developed to effectively capture both types of polar cell adhesions.
  When applied to specific cases of development – gastrulation and the or
 igins of folds and tubes – our theoretical tool suggests experimentally 
 testable predictions pointing to the strength of polar adhesion\, restrict
 ed directions of cell polarities\, and the rate of cell proliferation to b
 e major determinants of morphological diversity and stability.
LOCATION:MR19\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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