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SUMMARY:Persistent pneumococcal colonisation: Dynamics\, genomic diversity
  and evolution - Dr Chrispin Chaguza (Wellcome Sanger Institute\, Cambridg
 e)
DTSTART:20190516T121000Z
DTEND:20190516T130000Z
UID:TALK122875@talks.cam.ac.uk
CONTACT:Domi Baretic
DESCRIPTION:Bacterial evolution is a never-ending process and such innovat
 ion can lead to adaptation to clinical interventions such as antibiotics a
 nd vaccines thereby making them less effective. Streptococcus pneumoniae (
 the pneumococcus) is a human-adapted opportunistic pathogen once assigned 
 the moniker “Captain of the men of death” by Sir William Osler because
  of its high death toll globally. Despite significant reduction of the inv
 asive pneumococcal diseases (IPD) over the last two decades due to the int
 roduction of effective higher-valent pneumococcal vaccines (PCVs)\, IPDs c
 ontinue to kill hundreds of thousands of people globally. In this talk\, I
  will describe colonisation dynamics\, genomic diversity and evolution of 
 the pneumococcus during persistent colonisation episodes in infants from a
  low-income and tropical Sub Saharan African setting with high carriage an
 d disease burden during the first year of life.
LOCATION:The Richard King Room\, Darwin College
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