BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Deciphering the structure-function relationships of lncRNAs - John
  Mattick\, Green Templeton College\, University of Oxford
DTSTART:20190418T170000Z
DTEND:20190418T190000Z
UID:TALK122950@talks.cam.ac.uk
CONTACT:Giulia Furlan
DESCRIPTION:It is now clear that the majority of the genome is differentia
 lly and dynamically transcribed to produce not only mRNAs but also tens if
  not hundreds of thousands of short and long non-protein-coding RNAs that 
 show specific expression patterns and subcellular locations\, with many sh
 own to play important etiological roles in development\, brain function\, 
 cancer and other diseases. These noncoding RNAs function at many different
  levels of gene expression and cell biology\, including translational cont
 rol\, subcellular domain formation\, and guidance of the epigenetic proces
 ses that underpin development\, brain function and physiological adaptatio
 n. I will present recent data that indicates that exons in long noncoding 
 RNAs are near-universally spliced\, suggesting that the exon is the modula
 r unit of function\, which is supported by analysis of evolutionarily cons
 erved RNA structures\, and which provides a rational framework for determi
 ning their domains and interactions.
LOCATION:Gurdon Institute Tea Room
END:VEVENT
END:VCALENDAR