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SUMMARY:Visualising Genome Folding Dynamics in Mammalian Cells - Theory an
 d Experiments - Dr. Rosana Collepardo (University of Cambridge) &amp\; Dr.
  Srinjan Basu (University of Cambridge)
DTSTART:20190502T170000Z
DTEND:20190502T190000Z
UID:TALK123886@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:Reading the genome is one thing\, finding out how it functions
  is something else altogether. The three-dimensional organisation of the g
 enome is one of the great marvels of physical biology. To fit inside tiny 
 (6 μm) nuclei\, the metre-long DNA folds in a way that avoids\nentangleme
 nt and maintains exquisite control over the accessibility of the informati
 on it carries. Genome folding is intimately linked to gene function regula
 tion. However\, how the genome is organized in space and how this organiza
 tion influences its function remains unclear. In this talk\, we will descr
 ibe advances in multiscale computational modelling and in experimental app
 roaches such as single-cell Hi-C and single-molecule imaging\nthat allow u
 s for the first time to visualise the dynamics of the genome.
LOCATION:Panton Arms\, 43 Panton St\, Cambridge CB2 1HL
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