BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Computational Neuroscience Journal Club - Gido van de Ven
DTSTART:20190430T150000Z
DTEND:20190430T160000Z
UID:TALK124009@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:Gido van de Ven will present:\n\n• Hippocampal Reactivation 
 of Random Trajectories Resembling Brownian Diffusion\n\n• Federico Stell
 a\, Peter Baracskay\, Joseph O’Neill\, and Jozsef Csicsvari\n\n• Neuro
 n (2019)\n\n• https://www.sciencedirect.com/science/article/pii/S0896627
 319300790\n\n\nAbstract: Hippocampal activity patterns representing moveme
 nt trajectories are reactivated in immobility and sleep periods\, a proces
 s associated with memory recall\, consolidation\, and decision making. It 
 is thought that only fixed\, behaviorally relevant patterns can be reactiv
 ated\, which are stored across hippocampal synaptic connections. To test w
 hether some generalized rules govern reactivation\, we examined trajectory
  reactivation following non-stereotypical exploration of familiar open-fie
 ld environments. We found that random trajectories of varying lengths and 
 timescales were reactivated\, resembling that of Brownian motion of partic
 les. The animals’ behavioral trajectory did not follow Brownian diffusio
 n demonstrating that the exact behavioral experience is not reactivated. T
 herefore\, hippocampal circuits are able to generate random trajectories o
 f any recently active map by following diffusion dynamics. This ability of
  hippocampal circuits to generate representations of all behavioral outcom
 e combinations\, experienced or not\, may underlie a wide variety of hippo
 campal-dependent cognitive functions such as learning\, generalization\, a
 nd planning.
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
END:VEVENT
END:VCALENDAR