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SUMMARY:How Listeria sense the environment-to-host transition via PrfA - P
 rofessor Jose Vazquez-Boland\, Chair of Infectious Diseases\, University o
 f Edinburgh
DTSTART:20190515T150000Z
DTEND:20190515T160000Z
UID:TALK124093@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:The foodborne pathogen Listeria monocytogenes controls the exp
 ression of its virulence genes through PrfA\, a transcriptional regulator 
 of the Crp/Fnr family. PrfA is essential for activation of the listerial v
 irulence programme on entry into the host but is equally important in prev
 enting the cost of unneeded virulence factors in the environment. This pre
 sentation will discuss the inner workings of PrfA\, including new data fro
 m my laboratory showing that Listeria exploit the peptide composition of t
 he habitat to sense niche transitions and allosterically regulate PrfA act
 ivity accordingly. I shall also talk about an unexpected translational app
 lication of our PrfA research in the antibiotic therapy of listeriosis.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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