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SUMMARY:Genetic analysis of a conserved protein reveals an important role 
 in Plasmodium falciparum merozoite invasion of the host red blood cell - D
 r Danny Wilson\; Laboratory Head - Malaria Biology\, Research Centre for I
 nfectious Diseases\, School of Biological Sciences\, The University of Ade
 laide\, Australia
DTSTART:20190521T110000Z
DTEND:20190521T120000Z
UID:TALK124825@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION: \n \n\n\nThe disease-causing blood stage of the Plasmodium fa
 lciparum malaria parasite lifecycle is reliant on initial invasion of the 
 human red blood cell (RBC). Invasion of the host RBC by malaria merozoites
  is a rapid process that requires co-ordinated interactions between a larg
 e number of proteins\, many of which have no known function. We have chara
 cterised a protein (Peripherally Associated Rhoptry bulb Protein or PfPARP
 1) as wrapping around the cytosolic face of the club shaped rhoptry bulb m
 embrane\, a key organelle that excretes merozoite vaccine candidates durin
 g invasion. PfPARP1 lies in close juxtaposition with the rhoptry lumen mar
 ker PfRAP1. Attempts to knock-out PfPARP1 were unsuccessful\, but glucosam
 ine inducible PfPARP1 knock-down led to a significant growth defect that w
 as caused by direct loss of merozoite invasion. Knock-down of PfPARP1 was 
 associated with changes in rhoptry antigen structure\, suggesting that PfP
 ARP1 may have a direct role in rhoptry function that is essential to invas
 ion.  
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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