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SUMMARY:Regulation of B cell responses by distinct populations of T cells 
 - Dr Nicolas Fazilleau\; Deputy director of The Physiopathology Center of 
 Toulouse-Purpan
DTSTART:20190717T110000Z
DTEND:20190717T120000Z
UID:TALK124846@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Maturation of B cells in Germinal Centers (GC) is a hallmark i
 n adaptive immunity and the basis of successful vaccines that protect us a
 gainst lethal infections. Therefore it is key to understand how B cell sel
 ection takes place in GCs in order to develop new and fully protective vac
 cines. \nThe cellular mechanisms that control B cell selection are perform
 ed by different T cell populations. On one side\, cognate interaction of B
  cells with T follicular helper (Tfh) cells promotes survival\, proliferat
 ion\, mutagenesis and terminal differentiation of GC B cells. On the other
  hand\, regulatory T cells have also been reported within GC and interfere
  with T cell help for antibody production. These cells have been called T 
 Follicular regulatory cells (Tfr). During this seminar\, we will discuss t
 he established phenotypes and functions of Tfh cells and Tfr cells\, empha
 sizing the complementary role of these two cell populations in the GC.\n
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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