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SUMMARY:The fidelity of human mitochondrial gene expression - Dr Brendan B
 attersby | University of Helsinki
DTSTART:20191010T140000Z
DTEND:20191010T150000Z
UID:TALK124942@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:A defining feature of the eukaryotic cell is compartmentalised
  genomes with distinct modes of expression\, transmission and evolution. A
 nimal mitochondria possess one of the most simplified genomes in cellular 
 life that is essential for cell fitness. Despite the genome simplicity\, t
 he mechanisms coordinating mitochondrial gene expression remain significan
 t outstanding biological questions. Over the last decade\, the revolution 
 in genetic diagnostics revealed defects to mitochondrial gene expression m
 anifest as an exceptionally large group of heterogeneous diseases that dif
 fer in severity\, age of onset and tissue specificity. In all cases\, thes
 e diseases are associated with a quantitative reduction in the oxidative p
 hosphorylation complexes because of impaired protein synthesis on mitochon
 drial ribosomes. However\, the biochemical defect alone cannot account for
  the exceptional clinical presentations observed in patients. This suggest
 s additional factors underpin the molecular pathogenesis. Research from my
  laboratory points to the key role post-transcriptional and co-translation
 al quality control mechanisms play in the regulation of mitochondrial gene
  expression. The current focus of my research is to identify the molecular
  basis by which errors in mitochondrial gene expression are generated\, re
 cognised and resolved\, and the importance of these mechanisms in human he
 alth and disease.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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