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SUMMARY:Mitochondrial membrane musings - Dr Steven Claypool | John Hopkins
  University\, Baltimore USA
DTSTART:20190717T140000Z
DTEND:20190717T150000Z
UID:TALK124948@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Beyond energy\, the mitochondrion is also a powerhouse of phos
 pholipid biosynthesis. The mitochondrion is the home for one of the two ma
 jor phosphatidylethanolamine (PE) biosynthetic pathways in cells and is th
 e sole site of production of the dimeric phospholipid\, cardiolipin (CL). 
 Mutations that specifically impair normal mitochondrial phospholipid metab
 olism represent an emerging class of mitochondrial disease. Barth syndrome
 \, an X-linked childhood cardiomyopathy caused by mutations in the gene th
 at encodes the CL remodeling enzyme TAZ\, was the founding member of this 
 new category of human disease. More recently\, mutations in the gene that 
 encodes the mitochondrial enzyme that makes PE\, PISD\, have been determin
 ed to cause a novel mitochondrial chaperonopathy. Thus\, human genetics ha
 s made it clear that normal mitochondrial phospholipid metabolism as a who
 le is clinically important. Our goal is to obtain a detailed mechanistic u
 nderstanding of how individual phospholipids support the myriad of protein
 s\, protein complexes\, and functions that occur within and across mitocho
 ndrial membranes. Such information is needed to fully understand the numer
 ous roles played by phospholipids in both healthy and disease states.
LOCATION:Sackler Lecture Theatre (Level 7) The Keith Peters Building\, Cam
 bridge Biomedical Campus
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