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SUMMARY:Black Spot\, Black Death\, Black Pearl: The Tales of Bacterial Eff
 ectors - Kim Orth (UTSouthwestern)
DTSTART:20190528T090000Z
DTEND:20190528T100000Z
UID:TALK125209@talks.cam.ac.uk
CONTACT:82210
DESCRIPTION:My lab is interested in learning how cells function and transm
 it signals. It turns out that many novel mechanisms can be discovered by a
 nalyzing virulence factors or toxins used by pathogens during infections t
 o manipulate “normal” cells. We have found that these virulence factor
 s or toxins many times mimic or capture an activity used by host cells. Th
 ey then use this activity in clever ways during infection. For example\, A
 MPylation (covalently attaching AMP to an amino acid side chain of a prote
 in) is an ancient mechanism that we are re-discovering by studying pathoge
 ns. While bacterial pathogens hijacked this activity to shut down signalin
 g in an infected host cell\, the eukaryotic host\, such as Drosophila\, us
 es this same activity to maintain neuronal plasticity during chronic stres
 s.  My lab uses many techniques including\, biochemistry\, microbiology\, 
 microscopy\, yeast genetics\, cell biology\, proteomics\, biophysics\, etc
 \, to uncover these ingenious molecular activities.
LOCATION:Sanger Lecture Room\, MRC Laboratory of Molecular Biology\, Cambr
 idge Biomedical Campus
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