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SUMMARY:Dissecting the host response during pathogen-specific mastitis in 
 cows - Dr Wolfram Petzl\, Ludwig (Maximillians-Universitat Munich (LMU))
DTSTART:20191113T160000Z
DTEND:20191113T170000Z
UID:TALK125836@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Experimental in vivo infection models have been widely proven 
 as an effective tool for the investigation of pathogen-specific host immun
 e responses during bovine mastitis. Staphylococcus aureus (S. aureus) and 
 Escherichia coli (E. coli) are two common mastitis pathogens with an oppos
 ite clinical outcome of the disease. E. coli and S. aureus have proven to 
 be valid surrogates to model clinical and subclinical mastitis respectivel
 y. Transcriptome profiling studies demonstrated that the transcriptional r
 esponse in the teat reflects the course of pathogen-specific mastitis\, be
 ing ultimately determined by the immune response of the mammary epithelial
  cells. After experimental in vivo challenge\, E. coli induces a vigorous 
 early transcriptional response in udder tissue being quantitatively and qu
 alitatively distinct from the much weaker response against an S. aureus in
 tramammary infection. E. coli mastitis models proved that the local respon
 se in the infected udder quarters is accompanied by a response in non-infe
 cted neighbouring udder quarters modulating systemically their immune resp
 onsiveness. This insight resulted in the approach to prime tissue resident
  cells with pathogen-derived molecules to achieve temporary protection of 
 the udder in increasing the expression of endogenous antimicrobial peptide
 s and lowering of the severity of an eventually occurring inflammatory res
 ponse. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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