BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Detection of Alzheimer’s Protein Biomarker Clusterin using novel
  Graphene Biosensors - Shakil A. Awan\, Wolfson Nanomaterials &amp\; Devic
 es Laboratory\, School of Computing\, Electronics and Mathematics\, Univer
 sity of Plymouth
DTSTART:20190620T100000Z
DTEND:20190620T110000Z
UID:TALK126292@talks.cam.ac.uk
CONTACT:Pietro Sormanni
DESCRIPTION:Worldwide prevalence of dementia is estimated to rise from the
  current 50 million people affected to 152 million by 2050\, costing healt
 hcare systems ~2% of the global GDP to diagnose\, treat and care for patie
 nts [1]. Although there are over 130 different types of dementias\, Alzhei
 mer’s disease (AD) accounts for 60-70% of all cases. Methods for early d
 iagnosis of AD could significantly impact disease detection\, progression 
 monitoring and therapeutics. For these applications we are currently devel
 oping novel graphene sensors that can detect protein biomarker concentrati
 on changes in serum/plasma samples (compared to samples from healthy patie
 nts) with high sensitivity and specificity [2-4]. The aim of this talk is 
 to present a brief overview of graphene electronic properties and why they
  may be important for applications in protein biomarker detection. The tal
 k will then detail our approach for ultra-sensitive detection of proteins 
 to ~10fg/mL level\, fabrication of the graphene sensors\, latest results o
 n Clusterin (and hCG cancer biomarker [5]) and future directions of the re
 search in terms of molecular dynamics simulations and multiplexing of the 
 graphene sensors for point-of-care applications in the near future.\n\nWe 
 acknowledge funding from the UK’s EPSRC EP/M006301/1 and University of P
 lymouth\, GD105227.\n\nReferences\n\n[1] World Alzheimer’s Report 2018\,
  Alzheimer’s Disease International\, Sept 2018.\n\n[2] Haslam C.\, Awan 
 S.A.\, et al.\, “Label-free sensors based on graphene field-effect trans
 istors for the detection\nof Human Chorionic Gonadotropin cancer risk biom
 arker”\, Diagnostics\, 8\, 5\, 1-13\, 2018.\n\n[3] Awan S. A.\, Lombardo
  A.\, et al.\, “Transport conductivity of graphene at RF and microwave f
 requencies”\, 2D\nMater.\, 3 (1)\, 015010-1-11\, 2016.\n\n[4] Awan S. A.
 \, Kibble B. P. and Schürr J.\, “Coaxial Electrical Circuits for Interf
 erence-Free Measurements”\,\nBook\, Institution of Engineering and Techn
 ology\, March 2011\, ISBN: 1849190690.\n\n[5] Damiati S.\, Awan S. A. et a
 l.\, “Sensitivity Comparison of Macro- and Micro-electrochemical Biosens
 ors for\nHuman Chorionic Gonadotropin (hCG) Biomarker Detection”\, submi
 tted. arXiv announcement 7/6/19.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
END:VEVENT
END:VCALENDAR